Block of K(v)1.7 potassium currents increases glucose-stimulated insulin secretion

Glucose-stimulated insulin secretion (GSIS) relies on repetitive, electrical spiking activity of the beta cell membrane. Cyclic activation of voltage-gated potassium channels (K(v)) generates an outward, ‘delayed rectifier’ potassium current, which drives the repolarizing phase of each spike and mod...

Descripción completa

Detalles Bibliográficos
Autores principales: Finol-Urdaneta, Rocio K, Remedi, Maria S, Raasch, Walter, Becker, Stefan, Clark, Robert B, Strüver, Nina, Pavlov, Evgeny, Nichols, Colin G, French, Robert J, Terlau, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403299/
https://www.ncbi.nlm.nih.gov/pubmed/22438204
http://dx.doi.org/10.1002/emmm.201200218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403299/
https://www.ncbi.nlm.nih.gov/pubmed/22438204
http://dx.doi.org/10.1002/emmm.201200218

Ejemplares similares