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New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy
Activation of the p53 signaling pathway by DNA-damaging agents was originally proposed to result either in cell cycle checkpoint activation to promote survival or in apoptotic cell death. This model provided the impetus for numerous studies focusing on the development of p53-based cancer therapies....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403320/ https://www.ncbi.nlm.nih.gov/pubmed/22911014 http://dx.doi.org/10.1155/2012/170325 |