Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles

The therapeutic performance of oxaliplatin can be improved by incorporating the central cis-dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) motif into the core cross-linked block copolymer micelles. We describe here the preparation, cellular uptake, and in vivo evaluation of core cross-linked...

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Autores principales: Oberoi, Hardeep S., Nukolova, Natalia V., Zhao, Yi, Cohen, Samuel M., Kabanov, Alexander V., Bronich, Tatiana K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403332/
https://www.ncbi.nlm.nih.gov/pubmed/22844591
http://dx.doi.org/10.1155/2012/905796
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author Oberoi, Hardeep S.
Nukolova, Natalia V.
Zhao, Yi
Cohen, Samuel M.
Kabanov, Alexander V.
Bronich, Tatiana K.
author_facet Oberoi, Hardeep S.
Nukolova, Natalia V.
Zhao, Yi
Cohen, Samuel M.
Kabanov, Alexander V.
Bronich, Tatiana K.
author_sort Oberoi, Hardeep S.
collection PubMed
description The therapeutic performance of oxaliplatin can be improved by incorporating the central cis-dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) motif into the core cross-linked block copolymer micelles. We describe here the preparation, cellular uptake, and in vivo evaluation of core cross-linked micelles loaded with DACHPt. Stable drug-loaded micelles were prepared at high drug loading (~25 w/w%) and displayed a considerably increased in vitro cytotoxicity compared to free oxaliplatin against A2780 ovarian cancer cells. The DACHPt-loaded micelle formulation was well tolerated in mice and exhibited improved antitumor activity than oxaliplatin alone in an ovarian tumor xenograft model.
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spelling pubmed-34033322012-07-27 Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles Oberoi, Hardeep S. Nukolova, Natalia V. Zhao, Yi Cohen, Samuel M. Kabanov, Alexander V. Bronich, Tatiana K. Chemother Res Pract Research Article The therapeutic performance of oxaliplatin can be improved by incorporating the central cis-dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt) motif into the core cross-linked block copolymer micelles. We describe here the preparation, cellular uptake, and in vivo evaluation of core cross-linked micelles loaded with DACHPt. Stable drug-loaded micelles were prepared at high drug loading (~25 w/w%) and displayed a considerably increased in vitro cytotoxicity compared to free oxaliplatin against A2780 ovarian cancer cells. The DACHPt-loaded micelle formulation was well tolerated in mice and exhibited improved antitumor activity than oxaliplatin alone in an ovarian tumor xenograft model. Hindawi Publishing Corporation 2012 2012-07-15 /pmc/articles/PMC3403332/ /pubmed/22844591 http://dx.doi.org/10.1155/2012/905796 Text en Copyright © 2012 Hardeep S. Oberoi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Oberoi, Hardeep S.
Nukolova, Natalia V.
Zhao, Yi
Cohen, Samuel M.
Kabanov, Alexander V.
Bronich, Tatiana K.
Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
title Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
title_full Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
title_fullStr Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
title_full_unstemmed Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
title_short Preparation and In Vivo Evaluation of Dichloro(1,2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles
title_sort preparation and in vivo evaluation of dichloro(1,2-diaminocyclohexane)platinum(ii)-loaded core cross-linked polymer micelles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403332/
https://www.ncbi.nlm.nih.gov/pubmed/22844591
http://dx.doi.org/10.1155/2012/905796
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