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Apolipoprotein E: Essential Catalyst of the Alzheimer Amyloid Cascade
The amyloid cascade hypothesis remains a robust model of AD neurodegeneration. However, amyloid deposits contain proteins besides Aβ, such as apolipoprotein E (apoE). Inheritance of the apoE4 allele is the strongest genetic risk factor for late-onset AD. However, there is no consensus on how differe...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403541/ https://www.ncbi.nlm.nih.gov/pubmed/22844635 http://dx.doi.org/10.1155/2012/489428 |