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Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4(+)CD8(+) thymocytes

BACKGROUND: The outcome of untreated HIV-1 infection is progression to AIDS and death in nearly all cases. Some important exceptions are the small number of patients infected with HIV-1 deleted for the accessory gene, nef. With these infections, disease progression is entirely suppressed or greatly...

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Detalles Bibliográficos
Autores principales: Zou, Wei, Denton, Paul W, Watkins, Richard L, Krisko, John F, Nochi, Tomonori, Foster, John L, Garcia, J Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403983/
https://www.ncbi.nlm.nih.gov/pubmed/22640559
http://dx.doi.org/10.1186/1742-4690-9-44