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Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn(2+) in cognitively intact aged individuals with Alzheimer’s disease neuropathology

BACKGROUND: Early cognitive impairment in Alzheimer Disease (AD) is thought to result from the dysfunctional effect of amyloid beta (Aβ) oligomers targeting the synapses. Some individuals, however, escape cognitive decline despite the presence of the neuropathologic features of AD (Aβ plaques and ne...

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Detalles Bibliográficos
Autores principales: Bjorklund, Nicole L, Reese, Lindsay C, Sadagoparamanujam, V-M, Ghirardi, Valeria, Woltjer, Randall L, Taglialatela, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403985/
https://www.ncbi.nlm.nih.gov/pubmed/22640423
http://dx.doi.org/10.1186/1750-1326-7-23