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Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn(2+) in cognitively intact aged individuals with Alzheimer’s disease neuropathology
BACKGROUND: Early cognitive impairment in Alzheimer Disease (AD) is thought to result from the dysfunctional effect of amyloid beta (Aβ) oligomers targeting the synapses. Some individuals, however, escape cognitive decline despite the presence of the neuropathologic features of AD (Aβ plaques and ne...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403985/ https://www.ncbi.nlm.nih.gov/pubmed/22640423 http://dx.doi.org/10.1186/1750-1326-7-23 |