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Splice Variants of Na(V)1.7 Sodium Channels Have Distinct β Subunit-Dependent Biophysical Properties

Genes encoding the α subunits of neuronal sodium channels have evolutionarily conserved sites of alternative splicing but no functional differences have been attributed to the splice variants. Here, using Na(V)1.7 as an exemplar, we show that the sodium channel isoforms are functionally distinct whe...

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Detalles Bibliográficos
Autores principales: Farmer, Clare, Cox, James J., Fletcher, E. V., Woods, C. Geoffrey, Wood, John N., Schorge, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404004/
https://www.ncbi.nlm.nih.gov/pubmed/22911851
http://dx.doi.org/10.1371/journal.pone.0041750