N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler

Limited uncoupling of oxidative phosphorylation could be beneficial for cells by preventing excessive generation of reactive oxygen species. Typical uncouplers are weak organic acids capable of permeating across membranes with a narrow gap between efficacy and toxicity. Aimed at designing a nontoxic...

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Detalles Bibliográficos
Autores principales: Sorochkina, Alexandra I., Plotnikov, Egor Y., Rokitskaya, Tatyana I., Kovalchuk, Sergei I., Kotova, Elena A., Sychev, Sergei V., Zorov, Dmitry B., Antonenko, Yuri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404012/
https://www.ncbi.nlm.nih.gov/pubmed/22911866
http://dx.doi.org/10.1371/journal.pone.0041919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404012/
https://www.ncbi.nlm.nih.gov/pubmed/22911866
http://dx.doi.org/10.1371/journal.pone.0041919

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