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Structure and Dynamics of Amyloid-β Segmental Polymorphisms
It is believed that amyloid-beta (Aβ) aggregates play a role in the pathogenesis of Alzheimer’s disease. Aβ molecules form β-sheet structures with multiple interaction sites. This polymorphism gives rise to differences in morphology, physico-chemical property and level of cellular toxicity. We have...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404032/ https://www.ncbi.nlm.nih.gov/pubmed/22911797 http://dx.doi.org/10.1371/journal.pone.0041479 |