Temporal Separation of Aggregation and Ubiquitination during Early Inclusion Formation in Transgenic Mice Carrying the Huntington’s Disease Mutation

Abnormal insoluble ubiqitinated protein aggregates are found in the brains of Huntington’s disease (HD) patients and in mice transgenic for the HTT mutation. Here, we describe the earliest stages of visible NII formation in brains of R6/2 mice killed between 2 and 6 weeks of age. We found that hunti...

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Detalles Bibliográficos
Autores principales: Gong, Belvin, Kielar, Catherine, Morton, A. Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404089/
https://www.ncbi.nlm.nih.gov/pubmed/22848498
http://dx.doi.org/10.1371/journal.pone.0041450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404089/
https://www.ncbi.nlm.nih.gov/pubmed/22848498
http://dx.doi.org/10.1371/journal.pone.0041450

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