Automated Screening of Microtubule Growth Dynamics Identifies MARK2 as a Regulator of Leading Edge Microtubules Downstream of Rac1 in Migrating Cells

Polarized microtubule (MT) growth in the leading edge is critical to directed cell migration, and is mediated by Rac1 GTPase. To find downstream targets of Rac1 that affect MT assembly dynamics, we performed an RNAi screen of 23 MT binding and regulatory factors and identified RNAi treatments that s...

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Detalles Bibliográficos
Autores principales: Nishimura, Yukako, Applegate, Kathryn, Davidson, Michael W., Danuser, Gaudenz, Waterman, Clare M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404095/
https://www.ncbi.nlm.nih.gov/pubmed/22848487
http://dx.doi.org/10.1371/journal.pone.0041413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404095/
https://www.ncbi.nlm.nih.gov/pubmed/22848487
http://dx.doi.org/10.1371/journal.pone.0041413

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