Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors

The rapid proliferation of progenitors during neurogenesis requires a stringent genomic maintenance program to ensure transmission of genetic fidelity. However the essential factors that govern neural progenitor genome integrity are unknown. Here we report that conditional inactivation of mouse TopB...

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Detalles Bibliográficos
Autores principales: Lee, Youngsoo, Katyal, Sachin, Downing, Susanna M., Zhao, Jingfeng, Russell, Helen R., McKinnon, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404252/
https://www.ncbi.nlm.nih.gov/pubmed/22522401
http://dx.doi.org/10.1038/nn.3097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404252/
https://www.ncbi.nlm.nih.gov/pubmed/22522401
http://dx.doi.org/10.1038/nn.3097

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