Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

Failure of elimination of amyloid-β (Aβ) from the brain and vasculature appears to be a key factor in the etiology of sporadic Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA). In addition to age, possession of an apolipoprotein E (APOE) ε4 allele is a strong risk factor for the develo...

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Detalles Bibliográficos
Autores principales: Hawkes, Cheryl A., Sullivan, Patrick M., Hands, Sarah, Weller, Roy O., Nicoll, James A. R., Carare, Roxana O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404985/
https://www.ncbi.nlm.nih.gov/pubmed/22848551
http://dx.doi.org/10.1371/journal.pone.0041636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404985/
https://www.ncbi.nlm.nih.gov/pubmed/22848551
http://dx.doi.org/10.1371/journal.pone.0041636

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