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The Odyssey of Hsp60 from Tumor Cells to Other Destinations Includes Plasma Membrane-Associated Stages and Golgi and Exosomal Protein-Trafficking Modalities
BACKGROUND: In a previous work we showed for the first time that human tumor cells secrete Hsp60 via exosomes, which are considered immunologically active microvesicles involved in tumor progression. This finding raised questions concerning the route followed by Hsp60 to reach the exosomes, its loca...
Autores principales: | Campanella, Claudia, Bucchieri, Fabio, Merendino, Anna M., Fucarino, Alberto, Burgio, Giosalba, Corona, Davide F. V., Barbieri, Giovanna, David, Sabrina, Farina, Felicia, Zummo, Giovanni, de Macario, Everly Conway, Macario, Alberto J. L., Cappello, Francesco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405006/ https://www.ncbi.nlm.nih.gov/pubmed/22848686 http://dx.doi.org/10.1371/journal.pone.0042008 |
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