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Mapping MKP-3/FOXO1 Interaction and Evaluating the Effect on Gluconeogenesis
BACKGROUND: MAP kinase phosphatase 3 (MKP-3) is known to attenuate the ERK signaling pathway. It has been recently demonstrated that MKP-3 is also a player in promoting hepatic glucose output in obese state by interacting and activating FOXO1. Reduction of hepatic MKP-3 expression is sufficient to r...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405053/ https://www.ncbi.nlm.nih.gov/pubmed/22848439 http://dx.doi.org/10.1371/journal.pone.0041168 |