Structural Origins for the Loss of Catalytic Activities of Bifunctional Human LTA4H Revealed through Molecular Dynamics Simulations

Human leukotriene A4 hydrolase (hLTA4H), which is the final and rate-limiting enzyme of arachidonic acid pathway, converts the unstable epoxide LTA4 to a proinflammatory lipid mediator LTB4 through its hydrolase function. The LTA4H is a bi-functional enzyme that also exhibits aminopeptidase activity...

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Detalles Bibliográficos
Autores principales: Thangapandian, Sundarapandian, John, Shalini, Lazar, Prettina, Choi, Sun, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405069/
https://www.ncbi.nlm.nih.gov/pubmed/22848428
http://dx.doi.org/10.1371/journal.pone.0041063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405069/
https://www.ncbi.nlm.nih.gov/pubmed/22848428
http://dx.doi.org/10.1371/journal.pone.0041063

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