Aquaporin 4-Specific T Cells in Neuromyelitis Optica Exhibit a Th17 Bias and Recognize Clostridium ABC Transporter

OBJECTIVE: Aquaporin 4 (AQP4)-specific autoantibodies in neuromyelitis optica (NMO) are immunoglobulin (Ig)G1, a T cell-dependent Ig subclass, indicating that AQP4-specific T cells participate in NMO pathogenesis. Our goal was to identify and characterize AQP4-specific T cells in NMO patients and he...

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Detalles Bibliográficos
Autores principales: Varrin-Doyer, Michel, Spencer, Collin M, Schulze-Topphoff, Ulf, Nelson, Patricia A, Stroud, Robert M, C Cree, Bruce A, Zamvil, Scott S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Rapid Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405197/
https://www.ncbi.nlm.nih.gov/pubmed/22807325
http://dx.doi.org/10.1002/ana.23651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405197/
https://www.ncbi.nlm.nih.gov/pubmed/22807325
http://dx.doi.org/10.1002/ana.23651

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