TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex

BACKGROUND: p53 induces cell-cycle arrest and apoptosis in cancer cells and negatively regulates glycolysis via TIGAR. Glycolysis is crucial for cancer progression although TIGAR provides protection from reactive oxygen species and apoptosis. The relation between TIGAR-mediated inhibition of glycoly...

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Detalles Bibliográficos
Autores principales: Madan, E, Gogna, R, Kuppusamy, P, Bhatt, M, Pati, U, Mahdi, A A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405207/
https://www.ncbi.nlm.nih.gov/pubmed/22782351
http://dx.doi.org/10.1038/bjc.2012.260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405207/
https://www.ncbi.nlm.nih.gov/pubmed/22782351
http://dx.doi.org/10.1038/bjc.2012.260

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