Cargando…

Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation

BACKGROUND: Our earlier reports demonstrated that membrane-bound semaphorin 5A (SEMA5A) is expressed in aggressive pancreatic cancer cells and tumours, and promotes tumour growth and metastasis. In this study, we examine whether (1) pancreatic cancer cells secrete SEMA5A and (2) that secreted SEMA5A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sadanandam, A, Sidhu, S S, Wullschleger, S, Singh, S, Varney, M L, Yang, C-S, Ashour, A E, Batra, S K, Singh, R K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405228/ https://www.ncbi.nlm.nih.gov/pubmed/22782341 http://dx.doi.org/10.1038/bjc.2012.298

Ejemplares similares

Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis
por: Osawa, T, et al.
Publicado: (2013)

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion
por: Singh, S, et al.
Publicado: (2009)

MYB is a novel regulator of pancreatic tumour growth and metastasis
por: Srivastava, Sanjeev K, et al.
Publicado: (2015)

Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker?
por: Karayan-Tapon, L, et al.
Publicado: (2008)

Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells
por: Yamamoto, K, et al.
Publicado: (2012)

Identification of Semaphorin 5A Interacting Protein by Applying Apriori Knowledge and Peptide Complementarity Related to Protein Evolution and Structure
por: Sadanandam, Anguraj, et al.
Publicado: (2008)

Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer
por: Kaneda, H, et al.
Publicado: (2011)

CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer
por: Maeda, S, et al.
Publicado: (2008)

The correlation between cell-free DNA and tumour burden was estimated by PET/CT in patients with advanced NSCLC
por: Nygaard, A D, et al.
Publicado: (2014)

Tumour mutation status and sites of metastasis in patients with cutaneous melanoma
por: Adler, Nikki R, et al.
Publicado: (2017)

Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour)
por: Hong, H, et al.
Publicado: (2011)

Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis
por: Saxena, Sugandha, et al.
Publicado: (2017)

MicroRNA-211-5p suppresses tumour cell proliferation, invasion, migration and metastasis in triple-negative breast cancer by directly targeting SETBP1
por: Chen, Liang-liang, et al.
Publicado: (2017)

Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis
por: Walsh, N, et al.
Publicado: (2010)

Diabetogenic glucose and insulin concentrations modulate transcriptom and protein levels involved in tumour cell migration, adhesion and proliferation
por: Masur, K, et al.
Publicado: (2011)

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours
por: Weidlich, S, et al.
Publicado: (2011)

Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation
por: Christov, C P, et al.
Publicado: (2008)

Independent and functional validation of a multi-tumour-type proliferation signature
por: Starmans, M H W, et al.
Publicado: (2012)

The in situ local immune response, tumour senescence and proliferation in colorectal cancer
por: Roxburgh, C S, et al.
Publicado: (2013)

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis
por: Lee, Y S, et al.
Publicado: (2012)

Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis
por: Cao, R, et al.
Publicado: (2014)

Slow proliferation as a biological feature of colorectal cancer metastasis
por: Anjomshoaa, A, et al.
Publicado: (2009)

Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer
por: Greystoke, A, et al.
Publicado: (2012)

Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer
por: Tokumoto, Mao Watanabe, et al.
Publicado: (2015)

MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
por: Matull, W R, et al.
Publicado: (2008)

Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells
por: Kraan, J, et al.
Publicado: (2014)

MicroRNA-145 inhibits tumour growth and metastasis in colorectal cancer by targeting fascin-1
por: Feng, Y, et al.
Publicado: (2014)

Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors
por: Bijnsdorp, I V, et al.
Publicado: (2011)

Identification of the high-risk group for metastasis of gastric cancer cases by vascular endothelial growth factor receptor-1 overexpression in peripheral blood
por: Kosaka, Y, et al.
Publicado: (2007)

Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis
por: Srivastava, S K, et al.
Publicado: (2015)

The relationship between tumour necrosis, tumour proliferation, local and systemic inflammation, microvessel density and survival in patients undergoing potentially curative resection of oesophageal adenocarcinoma
por: Dutta, S, et al.
Publicado: (2012)

LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer
por: Ding, J, et al.
Publicado: (2013)

Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas
por: Handra-Luca, A, et al.
Publicado: (2011)

Diagnostic value of CA19.9, circulating tumour DNA and circulating tumour cells in patients with solid pancreatic tumours
por: Sefrioui, David, et al.
Publicado: (2017)

Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin
por: Bafna, S, et al.
Publicado: (2009)

Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients’ survival
por: Ren, J, et al.
Publicado: (2011)

Accumulation of small hyaluronan oligosaccharides in tumour interstitial fluid correlates with lymphatic invasion and lymph node metastasis
por: Schmaus, A, et al.
Publicado: (2014)

Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression
por: Wyler, L, et al.
Publicado: (2014)

Correlation between circulating mutant DNA and metabolic tumour burden in advanced non-small cell lung cancer patients
por: Winther-Larsen, Anne, et al.
Publicado: (2017)

MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells
por: Ponnusamy, M P, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_4grib2h5rvaniaf96dp8csscr6