Diosgenin is an exogenous activator of 1,25D(3)-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

The aim of this study was to investigate the effects and the mechanism of diosgenin, a famous plant-derived steroidal sapogenin, on memory deficits in Alzheimer's disease (AD) model mice. Diosgenin-treated 5XFAD mice exhibited significantly improved performance of object recognition memory. Dio...

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Detalles Bibliográficos
Autores principales: Tohda, Chihiro, Urano, Takuya, Umezaki, Masahito, Nemere, Ilka, Kuboyama, Tomoharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405293/
https://www.ncbi.nlm.nih.gov/pubmed/22837815
http://dx.doi.org/10.1038/srep00535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405293/
https://www.ncbi.nlm.nih.gov/pubmed/22837815
http://dx.doi.org/10.1038/srep00535

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