Binding Mode of CpG Oligodeoxynucleotides to Nanoparticles Regulates Bifurcated Cytokine induction via Toll-like Receptor 9

The interaction of cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) with Toll-like receptor 9 (TLR9) activates the immune system. Multimeric class A CpG ODNs induce interferon-α (IFN-α) and, to a lesser extent, interleukin-6. By contrast, monomeric class B CpG ODNs induce interleukin-6 bu...

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Detalles Bibliográficos
Autores principales: Chinnathambi, Shanmugavel, Chen, Song, Ganesan, Singaravelu, Hanagata, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405294/
https://www.ncbi.nlm.nih.gov/pubmed/22837814
http://dx.doi.org/10.1038/srep00534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405294/
https://www.ncbi.nlm.nih.gov/pubmed/22837814
http://dx.doi.org/10.1038/srep00534

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