Dihydropyrimidine dehydrogenase polymorphisms and fluoropyrimidine toxicity: ready for routine clinical application within personalized medicine?

Fluoropyrimidines, including 5-fluorouracil (5-FU), are widely used in the treatment of solid tumors and remain the backbone of many combination regimens. Despite their clinical benefit, fluoropyrimidines are associated with gastrointestinal and hematologic toxicities, which often lead to treatment...

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Detalles Bibliográficos
Autores principales: Del Re, Marzia, Di Paolo, Antonello, van Schaik, Ron H., Bocci, Guido, Simi, Paolo, Falcone, Alfredo, Danesi, Romano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405332/
https://www.ncbi.nlm.nih.gov/pubmed/23199091
http://dx.doi.org/10.1007/s13167-010-0041-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405332/
https://www.ncbi.nlm.nih.gov/pubmed/23199091
http://dx.doi.org/10.1007/s13167-010-0041-2

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