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Predictive diagnostics in colorectal cancer: impact of genetic polymorphisms on individual outcomes and treatment with fluoropyrimidine-based chemotherapy
The 5-fluorouracil (5-FU)-based chemotherapy is a standard treatment for patients with colorectal cancer. However, a relevant number of patients suffer from severe toxic side effects, such as haemotoxicity, while lacking clinical response to adjuvant therapy. The inter-individual variations of drug...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405340/ https://www.ncbi.nlm.nih.gov/pubmed/23199090 http://dx.doi.org/10.1007/s13167-010-0022-5 |