Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

BACKGROUND: Abnormal proteostasis due to alterations in protein turnover has been postulated to play a central role in several neurodegenerative diseases. Therefore, the development of techniques to quantify protein turnover in the brain is critical for understanding the pathogenic mechanisms of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Basak, Jacob M, Kim, Jungsu, Pyatkivskyy, Yuriy, Wildsmith, Kristin R, Jiang, Hong, Parsadanian, Maia, Patterson, Bruce W, Bateman, Randall J, Holtzman, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405485/
https://www.ncbi.nlm.nih.gov/pubmed/22512932
http://dx.doi.org/10.1186/1750-1326-7-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405485/
https://www.ncbi.nlm.nih.gov/pubmed/22512932
http://dx.doi.org/10.1186/1750-1326-7-14

Ejemplares similares