UNG shapes the specificity of AID-induced somatic hypermutation

Secondary diversification of antibodies through somatic hypermutation (SHM) and class switch recombination (CSR) is a critical component of the immune response. Activation-induced deaminase (AID) initiates both processes by deaminating cytosine residues in immunoglobulin genes. The resulting U:G mis...

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Detalles Bibliográficos
Autores principales: Pérez-Durán, Pablo, Belver, Laura, de Yébenes, Virginia G., Delgado, Pilar, Pisano, David G., Ramiro, Almudena R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405504/
https://www.ncbi.nlm.nih.gov/pubmed/22665573
http://dx.doi.org/10.1084/jem.20112253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405504/
https://www.ncbi.nlm.nih.gov/pubmed/22665573
http://dx.doi.org/10.1084/jem.20112253

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