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Dynamics and Calcium Association to the N-Terminal Regulatory Domain of Human Cardiac Troponin C: A Multiscale Computational Study

[Image: see text] Troponin C (TnC) is an important regulatory molecule in cardiomyocytes. Calcium binding to site II in TnC initiates a series of molecular events that result in muscle contraction. The most direct change upon Ca(2+) binding is an opening motion of the molecule that exposes a hydroph...

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Detalles Bibliográficos
Autores principales:	Lindert, Steffen, Kekenes-Huskey, Peter M., Huber, Gary, Pierce, Levi, McCammon, J. Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405770/ https://www.ncbi.nlm.nih.gov/pubmed/22329450 http://dx.doi.org/10.1021/jp212173f

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