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Brain-Specific Rescue of Clock Reveals System-Driven Transcriptional Rhythms in Peripheral Tissue

The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues. The nature of the relationship between central and peripheral oscillators, however, is poorly understood....

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Detalles Bibliográficos
Autores principales: Hughes, Michael E., Hong, Hee-Kyung, Chong, Jason L., Indacochea, Alejandra A., Lee, Samuel S., Han, Michael, Takahashi, Joseph S., Hogenesch, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405989/
https://www.ncbi.nlm.nih.gov/pubmed/22844252
http://dx.doi.org/10.1371/journal.pgen.1002835