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Brain-Specific Rescue of Clock Reveals System-Driven Transcriptional Rhythms in Peripheral Tissue
The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues. The nature of the relationship between central and peripheral oscillators, however, is poorly understood....
Autores principales: | Hughes, Michael E., Hong, Hee-Kyung, Chong, Jason L., Indacochea, Alejandra A., Lee, Samuel S., Han, Michael, Takahashi, Joseph S., Hogenesch, John B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405989/ https://www.ncbi.nlm.nih.gov/pubmed/22844252 http://dx.doi.org/10.1371/journal.pgen.1002835 |
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