Platelets Induce Apoptosis during Sepsis in a Contact-Dependent Manner That Is Inhibited by GPIIb/IIIa Blockade

PURPOSE: End-organ apoptosis is well-described in progressive sepsis and Multiple Organ Dysfunction Syndrome (MODS), especially where platelets accumulate (e.g. spleen and lung). We previously reported an acute sepsis-induced cytotoxic platelet phenotype expressing serine protease granzyme B. We now...

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Detalles Bibliográficos
Autores principales: Sharron, Matthew, Hoptay, Claire E., Wiles, Andrew A., Garvin, Lindsay M., Geha, Mayya, Benton, Angela S., Nagaraju, Kanneboyina, Freishtat, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406039/
https://www.ncbi.nlm.nih.gov/pubmed/22844498
http://dx.doi.org/10.1371/journal.pone.0041549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406039/
https://www.ncbi.nlm.nih.gov/pubmed/22844498
http://dx.doi.org/10.1371/journal.pone.0041549

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