Effect of Insulin Analogues on Insulin/IGF1 Hybrid Receptors: Increased Activation by Glargine but Not by Its Metabolites M1 and M2

BACKGROUND: In diabetic patients, the pharmacokinetics of injected human insulin does not permit optimal control of glycemia. Fast and slow acting insulin analogues have been developed, but they may have adverse properties, such as increased mitogenic or anti-apoptotic signaling. Insulin/IGF1 hybrid...

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Detalles Bibliográficos
Autores principales: Pierre-Eugene, Cécile, Pagesy, Patrick, Nguyen, Tuyet Thu, Neuillé, Marion, Tschank, Georg, Tennagels, Norbert, Hampe, Cornelia, Issad, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406060/
https://www.ncbi.nlm.nih.gov/pubmed/22848683
http://dx.doi.org/10.1371/journal.pone.0041992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406060/
https://www.ncbi.nlm.nih.gov/pubmed/22848683
http://dx.doi.org/10.1371/journal.pone.0041992

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