Cargando…

Tricyclic Pyrazoles. Part 5. Novel 1,4-Dihydroindeno[1,2-c]pyrazole CB2 Ligands Using Molecular Hybridization Based on Scaffold Hopping

In search of new selective CB2 ligands, the synthesis and preliminary biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazole hybrids of the highly potent prototypicals 5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-N-fenchyl-1H-pyrazole-3-carboxamide 1 and 1-(2,4-dichlorophenyl)-6-methyl-N-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murineddu, Gabriele, Asproni, Battistina, Ruiu, Stefania, Deligia, Francesco, Falzoi, Matteo, Pau, Amedeo, Thomas, Brian F, Zhang, Yanan, Pinna, Gérard A, Pani, Luca, Lazzari, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Open 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406267/ https://www.ncbi.nlm.nih.gov/pubmed/22876271 http://dx.doi.org/10.2174/1874104501206010001

Ejemplares similares

Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB(1)/CB(2) Receptor Interaction
por: Asproni, Battistina, et al.
Publicado: (2021)

Development of Oxygen-Bridged Pyrazole-Based Structures as Cannabinoid Receptor 1 Ligands
por: Murineddu, Gabriele, et al.
Publicado: (2019)

Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
por: Pinna, Giansalvo, et al.
Publicado: (2013)

Synthesis and Cytotoxicity of Novel Hexahydrothieno-cycloheptapyridazinone Derivatives
por: Pau, Amedeo, et al.
Publicado: (2009)

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds
por: Niculescu-Duvaz, Dan, et al.
Publicado: (2010)

1H-Pyrazol-2-ium hydrogen oxalate
por: Yu, Chun-Hua, et al.
Publicado: (2012)

2,2,2-Tris(pyrazol-1-yl)ethanol
por: McLauchlan, Craig C., et al.
Publicado: (2011)

Direct N-heterocyclization of hydrazines to access styrylated pyrazoles: synthesis of 1,3,5-trisubstituted pyrazoles and dihydropyrazoles
por: Venkateswarlu, Vunnam, et al.
Publicado: (2018)

Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamide and Isoxazolol Pyrazole Carboxylate
por: Sun, Jialong, et al.
Publicado: (2015)

New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways
por: Signorello, Maria Grazia, et al.
Publicado: (2021)

(3,5-Dimethylpyrazol-1-yl)[5-(3,5-dimethylpyrazol-1-ylcarbonyl)-2-thienyl]methanone
por: Guzei, Ilia A., et al.
Publicado: (2009)

On the Tautomerism of N-Substituted Pyrazolones: 1,2-Dihydro-3H-pyrazol-3-ones versus 1H-Pyrazol-3-ols
por: Arbačiauskienė, Eglė, et al.
Publicado: (2018)

1-Phenyl-1H-pyrazole-4-carbaldehyde
por: Asiri, Abdullah M., et al.
Publicado: (2012)

4-(1,3-Diphenyl-4,5-dihydro-1H-pyrazol-5-yl)-1,3-diphenyl-1H-pyrazole
por: Fun, Hoong-Kun, et al.
Publicado: (2011)

1-Benzoyl-3-(pyridin-2-yl)-1H-pyrazole
por: Shelton, Alexander H., et al.
Publicado: (2011)

1,5-Dimethyl-4-{[1-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylidene)ethyl]amino}-2-phenyl-1H-pyrazol-3(2H)-one
por: Zhu, Hualing, et al.
Publicado: (2010)

Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives
por: Piras, Sandra, et al.
Publicado: (2021)

Synthesis of Dihydrooxepino[3,2-c]Pyrazoles via Claisen Rearrangement and Ring-Closing Metathesis from 4-Allyloxy-1H-pyrazoles
por: Usami, Yoshihide, et al.
Publicado: (2018)

[Diphenyldi(pyrazol-1-yl)methane]dinitratocobalt(II)
por: Shaw, Janet L., et al.
Publicado: (2010)

Chlorido[hydridotris(pyrazol-1-yl-κN (2))borato](1H-pyrazole-κN (2))(triphenylphosphine-κP)ruthenium(II)
por: Huang, Chiung-Cheng, et al.
Publicado: (2010)

1,3-Diphenyl-1H-pyrazole-4-carbaldehyde
por: Ather, Abdul Qayyum, et al.
Publicado: (2010)

Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism
por: Tarabová, Denisa, et al.
Publicado: (2014)

Microbiological Screening of 5-Functionalized Pyrazoles for the Future Development of Optimized Pyrazole-Based Delivery Systems
por: Brullo, Chiara, et al.
Publicado: (2022)

2-(1H-Pyrazol-3-yl)pyridinium chloride monohydrate
por: Amarante, Tatiana R., et al.
Publicado: (2009)

5-Amino-1H-pyrazol-2-ium hydrogen succinate
por: Yamuna, Thammarse S., et al.
Publicado: (2014)

Antioxidant and Antimicrobial Activity of 5-methyl-2-(5-methyl-1,3-diphenyl-1H-pyrazole-4-carbonyl)-2,4-dihydro-pyrazol-3-one
por: Umesha, K. B., et al.
Publicado: (2009)

2-[3-(Pyridin-1-ium-2-yl)-1H-pyrazol-1-yl]-6-[3-(pyridin-2-yl)-1H-pyrazol-1-yl]pyridinium sulfate methanol monosolvate
por: Huang, Linxia, et al.
Publicado: (2013)

Evidence of Polymorphism on the Antitrypanosomal Naphthoquinone (4E)-2-(1H-Pyrazol-3-ylamino)-4-(1H-pyrazol-3-ylimino)naphthalen-1(4H)-one
por: Sperandeo, Norma R., et al.
Publicado: (2013)

5-Chloro-1-phenyl-1H-pyrazol-4-amine
por: Korzański, Artur, et al.
Publicado: (2011)

5-Chloromethyl-1,3-dimethyl-1H-pyrazole
por: Yang, Guiqiu, et al.
Publicado: (2010)

3-Chloro-6-(1H-pyrazol-1-yl)pyridazine
por: Ather, Abdul Qayyum, et al.
Publicado: (2010)

Dichlorido(3,5-dimethyl-1H-pyrazole)[(3,5-dimethyl-1H-pyrazol-1-yl)(o-tolyl)methanone]palladium(II)
por: Nelana, Simphiwe M., et al.
Publicado: (2007)

3,5-Dimethyl-4-nitroso-1H-pyrazole
por: Safyanova, Inna, et al.
Publicado: (2011)

4-Benzyl-3,5-dimethyl-1H-pyrazole
por: Wang, Su-Qing, et al.
Publicado: (2011)

Bis{4-[(3,5-dimethyl-1H-pyrazol-4-yl)selanyl]-3,5-dimethyl-1H-pyrazol-2-ium} chloride monohydrate
por: Seredyuk, Maksym, et al.
Publicado: (2012)

Crystal structure of bis{(3,5-dimethylpyrazol-1-yl)dihydro[3-(pyridin-2-yl)pyrazol-1-yl]borato}iron(II)
por: Ossinger, Sascha, et al.
Publicado: (2020)

2-[1-(9-Anthrylmethyl)-1H-pyrazol-3-yl]pyridine
por: Zhang, Shi-Lu, et al.
Publicado: (2009)

Synthesis of 1-(2-Fluorophenyl)pyrazoles by 1,3-Dipolar Cycloaddition of the Corresponding Sydnones
por: Dumitrescu, Denisa, et al.
Publicado: (2021)

Two tautomers in the same crystal: 3-(4-fluorophenyl)-1H-pyrazole and 5-(4-fluorophenyl)-1H-pyrazole
por: Yamuna, Thammarse S., et al.
Publicado: (2014)

Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest
por: Dias, Luiza Rosaria Sousa, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_j4ddk43ql68l50ink8uvc8kjrr