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Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis

Despite the importance of telomere maintenance in cancer cell survival via the elongation of telomeres by telomerase reverse transcriptase (TERT) or Alternative Lengthening of Telomeres (ALT), it had not been tested directly whether telomere maintenance is dispensable for human tumorigenesis. We eng...

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Detalles Bibliográficos
Autores principales: Taboski, Michael A. S., Sealey, David C. F., Dorrens, Jennifer, Tayade, Chandrakant, Betts, Dean H., Harrington, Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406325/
https://www.ncbi.nlm.nih.gov/pubmed/22832159
http://dx.doi.org/10.1016/j.celrep.2011.12.004