A Lys49-PLA(2) myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling

Lys49-PLA(2) myotoxins, an important component of various viperid snake venoms, are a class of PLA(2)-homolog proteins deprived of catalytic activity. Similar to enzymatically active PLA(2) (Asp49) and to other classes of myotoxins, they cause severe myonecrosis. Moreover, these toxins are used as t...

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Detalles Bibliográficos
Autores principales: Tonello, F, Simonato, M, Aita, A, Pizzo, P, Fernández, J, Lomonte, B, Gutiérrez, J M, Montecucco, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406575/
https://www.ncbi.nlm.nih.gov/pubmed/22764102
http://dx.doi.org/10.1038/cddis.2012.68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406575/
https://www.ncbi.nlm.nih.gov/pubmed/22764102
http://dx.doi.org/10.1038/cddis.2012.68

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