Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach

Centrosome amplification (CA) and resultant chromosomal instability have long been associated with tumorigenesis. However, exacerbation of CA and relentless centrosome declustering engender robust spindle multipolarity (SM) during mitosis and may induce cell death. Recently, we demonstrated that a n...

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Detalles Bibliográficos
Autores principales: Pannu, V, Rida, P C G, Ogden, A, Clewley, R, Cheng, A, Karna, P, Lopus, M, Mishra, R C, Zhou, J, Aneja, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406581/
https://www.ncbi.nlm.nih.gov/pubmed/22785532
http://dx.doi.org/10.1038/cddis.2012.82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406581/
https://www.ncbi.nlm.nih.gov/pubmed/22785532
http://dx.doi.org/10.1038/cddis.2012.82

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