Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells

Exploiting protein homeostasis is a new therapeutic approach in cancer. Nelfinavir (NFV) is an HIV protease inhibitor that induces endoplasmic reticulum (ER) stress in cancer cells. Under conditions of ER stress, misfolded proteins are transported from the ER back to the cytosol for subsequent degra...

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Detalles Bibliográficos
Autores principales: Kawabata, S, Gills, J J, Mercado-Matos, J R, LoPiccolo, J, Wilson, W, Hollander, M C, Dennis, P A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406586/
https://www.ncbi.nlm.nih.gov/pubmed/22825471
http://dx.doi.org/10.1038/cddis.2012.87

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406586/
https://www.ncbi.nlm.nih.gov/pubmed/22825471
http://dx.doi.org/10.1038/cddis.2012.87

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