Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells

Glucocorticoids (GCs) are common components of many chemotherapeutic regimens for lymphoid malignancies. GC-induced apoptosis involves an intrinsic mitochondria-dependent pathway. BIM (BCL-2-interacting mediator of cell death), a BCL-2 homology 3-only pro-apoptotic protein, is upregulated by dexamet...

Descripción completa

Detalles Bibliográficos
Autores principales: Heidari, N, Miller, A V, Hicks, M A, Marking, C B, Harada, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406588/
https://www.ncbi.nlm.nih.gov/pubmed/22825467
http://dx.doi.org/10.1038/cddis.2012.89

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406588/
https://www.ncbi.nlm.nih.gov/pubmed/22825467
http://dx.doi.org/10.1038/cddis.2012.89

Ejemplares similares