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Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses

BACKGROUND: RGS17 and RGS20 encode two members of the regulator of G-protein signaling RGS-Rz subfamily. Variation in these genes may alter their transcription and thereby influence the function of G protein-coupled receptors, including opioid receptors, and modify risk for substance dependence. MET...

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Autores principales: Zhang, Huiping, Wang, Fan, Kranzler, Henry R, Anton, Raymond F, Gelernter, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406967/
https://www.ncbi.nlm.nih.gov/pubmed/22591552
http://dx.doi.org/10.1186/1744-9081-8-23
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author Zhang, Huiping
Wang, Fan
Kranzler, Henry R
Anton, Raymond F
Gelernter, Joel
author_facet Zhang, Huiping
Wang, Fan
Kranzler, Henry R
Anton, Raymond F
Gelernter, Joel
author_sort Zhang, Huiping
collection PubMed
description BACKGROUND: RGS17 and RGS20 encode two members of the regulator of G-protein signaling RGS-Rz subfamily. Variation in these genes may alter their transcription and thereby influence the function of G protein-coupled receptors, including opioid receptors, and modify risk for substance dependence. METHODS: The association of 13 RGS17 and eight RGS20 tag single nucleotide polymorphisms (SNPs) was examined with four substance dependence diagnoses (alcohol (AD), cocaine (CD), opioid (OD) or marijuana (MjD)] in 1,905 African Americans (AAs: 1,562 cases and 343 controls) and 1,332 European Americans (EAs: 981 cases and 351 controls). Analyses were performed using both χ(2) tests and logistic regression analyses that covaried sex, age, and ancestry proportion. Correlation of genotypes and mRNA expression levels was assessed by linear regression analyses. RESULTS: Seven RGS17 SNPs showed a significant association with at least one of the four dependence traits after a permutation-based correction for multiple testing (0.003≤P(empirical)≤0.037). The G allele of SNP rs596359, in the RGS17 promoter region, was associated with AD, CD, OD, or MjD in both populations (0.005≤P(empirical)≤0.019). This allele was also associated with significantly lower mRNA expression levels of RGS17 in YRI subjects (P = 0.002) and non-significantly lower mRNA expression levels of RGS17 in CEU subjects (P = 0.185). No RGS20 SNPs were associated with any of the four dependence traits in either population. CONCLUSIONS: This study demonstrated that variation in RGS17 was associated with risk for substance dependence diagnoses in both AA and EA populations.
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spelling pubmed-34069672012-07-28 Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses Zhang, Huiping Wang, Fan Kranzler, Henry R Anton, Raymond F Gelernter, Joel Behav Brain Funct Research BACKGROUND: RGS17 and RGS20 encode two members of the regulator of G-protein signaling RGS-Rz subfamily. Variation in these genes may alter their transcription and thereby influence the function of G protein-coupled receptors, including opioid receptors, and modify risk for substance dependence. METHODS: The association of 13 RGS17 and eight RGS20 tag single nucleotide polymorphisms (SNPs) was examined with four substance dependence diagnoses (alcohol (AD), cocaine (CD), opioid (OD) or marijuana (MjD)] in 1,905 African Americans (AAs: 1,562 cases and 343 controls) and 1,332 European Americans (EAs: 981 cases and 351 controls). Analyses were performed using both χ(2) tests and logistic regression analyses that covaried sex, age, and ancestry proportion. Correlation of genotypes and mRNA expression levels was assessed by linear regression analyses. RESULTS: Seven RGS17 SNPs showed a significant association with at least one of the four dependence traits after a permutation-based correction for multiple testing (0.003≤P(empirical)≤0.037). The G allele of SNP rs596359, in the RGS17 promoter region, was associated with AD, CD, OD, or MjD in both populations (0.005≤P(empirical)≤0.019). This allele was also associated with significantly lower mRNA expression levels of RGS17 in YRI subjects (P = 0.002) and non-significantly lower mRNA expression levels of RGS17 in CEU subjects (P = 0.185). No RGS20 SNPs were associated with any of the four dependence traits in either population. CONCLUSIONS: This study demonstrated that variation in RGS17 was associated with risk for substance dependence diagnoses in both AA and EA populations. BioMed Central 2012-05-16 /pmc/articles/PMC3406967/ /pubmed/22591552 http://dx.doi.org/10.1186/1744-9081-8-23 Text en Copyright ©2012 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Zhang, Huiping
Wang, Fan
Kranzler, Henry R
Anton, Raymond F
Gelernter, Joel
Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
title Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
title_full Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
title_fullStr Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
title_full_unstemmed Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
title_short Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses
title_sort variation in regulator of g-protein signaling 17 gene (rgs17) is associated with multiple substance dependence diagnoses
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406967/
https://www.ncbi.nlm.nih.gov/pubmed/22591552
http://dx.doi.org/10.1186/1744-9081-8-23
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