Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression

BACKGROUND: Processive elongation of the integrated HIV-1 provirus is dependent on recruitment of P-TEFb by the viral Tat protein to the viral TAR RNA element. P-TEFb kinase activity requires phosphorylation of Thr186 in the T-loop of the CDK9 subunit. In resting CD4(+)T cells, low levels of T-loop...

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Detalles Bibliográficos
Autores principales: Budhiraja, Sona, Ramakrishnan, Rajesh, Rice, Andrew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406988/
https://www.ncbi.nlm.nih.gov/pubmed/22727189
http://dx.doi.org/10.1186/1742-4690-9-52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406988/
https://www.ncbi.nlm.nih.gov/pubmed/22727189
http://dx.doi.org/10.1186/1742-4690-9-52

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