Comprehensive Re-Sequencing of Adrenal Aldosterone Producing Lesions Reveal Three Somatic Mutations near the KCNJ5 Potassium Channel Selectivity Filter

BACKGROUND: Aldosterone producing lesions are a common cause of hypertension, but genetic alterations for tumorigenesis have been unclear. Recently, either of two recurrent somatic missense mutations (G151R or L168R) was found in the potassium channel KCNJ5 gene in aldosterone producing adenomas. Th...

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Detalles Bibliográficos
Autores principales: Åkerström, Tobias, Crona, Joakim, Delgado Verdugo, Alberto, Starker, Lee F., Cupisti, Kenko, Willenberg, Holger S., Knoefel, Wolfram T., Saeger, Wolfgang, Feller, Alfred, Ip, Julian, Soon, Patsy, Anlauf, Martin, Alesina, Pier F., Schmid, Kurt W., Decaussin, Myriam, Levillain, Pierre, Wängberg, Bo, Peix, Jean-Louis, Robinson, Bruce, Zedenius, Jan, Bäckdahl, Martin, Caramuta, Stefano, Iwen, K. Alexander, Botling, Johan, Stålberg, Peter, Kraimps, Jean-Louis, Dralle, Henning, Hellman, Per, Sidhu, Stan, Westin, Gunnar, Lehnert, Hendrik, Walz, Martin K., Åkerström, Göran, Carling, Tobias, Choi, Murim, Lifton, Richard P., Björklund, Peyman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407065/
https://www.ncbi.nlm.nih.gov/pubmed/22848660
http://dx.doi.org/10.1371/journal.pone.0041926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407065/
https://www.ncbi.nlm.nih.gov/pubmed/22848660
http://dx.doi.org/10.1371/journal.pone.0041926

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