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Regulation of Lean Mass, Bone Mass, and Exercise Tolerance by the Central Melanocortin System
Signaling via the type 4-melanocortin receptor (MC4R) is an important determinant of body weight in mice and humans, where loss of function mutations lead to significant obesity. Humans with mutations in the MC4R experience an increase in lean mass. However, the simultaneous accrual of fat mass in s...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407101/ https://www.ncbi.nlm.nih.gov/pubmed/22848742 http://dx.doi.org/10.1371/journal.pone.0042183 |