Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

Proprotein convertase subtilisin/kexin-9 (PCSK9) enhances the degradation of hepatic low-density lipoprotein receptor (LDLR). Deletion of PCSK9, and loss-of-function mutants in humans result in lower levels of circulating LDL-cholesterol and a strong protection against coronary heart disease. Accord...

Descripción completa

Detalles Bibliográficos
Autores principales: Seidah, Nabil G., Poirier, Steve, Denis, Maxime, Parker, Rex, Miao, Bowman, Mapelli, Claudio, Prat, Annik, Wassef, Hanny, Davignon, Jean, Hajjar, Katherine A., Mayer, Gaétan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407131/
https://www.ncbi.nlm.nih.gov/pubmed/22848640
http://dx.doi.org/10.1371/journal.pone.0041865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407131/
https://www.ncbi.nlm.nih.gov/pubmed/22848640
http://dx.doi.org/10.1371/journal.pone.0041865

Ejemplares similares