Hsp90 Is Cleaved by Reactive Oxygen Species at a Highly Conserved N-Terminal Amino Acid Motif

Hsp90 is an essential chaperone that is necessary for the folding, stability and activity of numerous proteins. In this study, we demonstrate that free radicals formed during oxidative stress conditions can cleave Hsp90. This cleavage occurs through a Fenton reaction which requires the presence of r...

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Detalles Bibliográficos
Autores principales: Beck, Raphaël, Dejeans, Nicolas, Glorieux, Christophe, Creton, Mélanie, Delaive, Edouard, Dieu, Marc, Raes, Martine, Levêque, Philippe, Gallez, Bernard, Depuydt, Matthieu, Collet, Jean-François, Calderon, Pedro Buc, Verrax, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407180/
https://www.ncbi.nlm.nih.gov/pubmed/22848402
http://dx.doi.org/10.1371/journal.pone.0040795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407180/
https://www.ncbi.nlm.nih.gov/pubmed/22848402
http://dx.doi.org/10.1371/journal.pone.0040795

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