Oligomeric Forms of Insulin Amyloid Aggregation Disrupt Outgrowth and Complexity of Neuron-Like PC12 Cells

Formation of protein amyloid fibrils consists of a series of intermediates including oligomeric aggregates, proto-fibrillar structures, and finally mature fibrils. Recent studies show higher toxicity for oligomeric and proto-fibrillar intermediates of protein relative to their mature fibrils. Here t...

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Detalles Bibliográficos
Autores principales: Kachooei, Ehsan, Moosavi-Movahedi, Ali Akbar, Khodagholi, Fariba, Ramshini, Hassan, Shaerzadeh, Fatemeh, Sheibani, Nader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407202/
https://www.ncbi.nlm.nih.gov/pubmed/22848469
http://dx.doi.org/10.1371/journal.pone.0041344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407202/
https://www.ncbi.nlm.nih.gov/pubmed/22848469
http://dx.doi.org/10.1371/journal.pone.0041344

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