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Zinc finger nucleases for targeted mutagenesis and repair of the sickle-cell disease mutation: An in-silico study
BACKGROUND: Sickle cell disease (or simply, SCD) is an inherited hemoglobinopathy which is mostly prevalent among persons of African descent. SCD results from a monogenic (Hemoglobin, beta) point-mutation (substitution of the base Adenine with Thymine at position six) that leads to replacement of th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407482/ https://www.ncbi.nlm.nih.gov/pubmed/22583379 http://dx.doi.org/10.1186/1471-2326-12-5 |