Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

BACKGROUND: A mutation in the BRI2/ITM2b gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer’s disease (AD) pathogenesis. The FDD mutation leads to a loss of BRI2 protein and to increased APP proce...

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Detalles Bibliográficos
Autores principales: Tamayev, Robert, D’Adamio, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407505/
https://www.ncbi.nlm.nih.gov/pubmed/22537414
http://dx.doi.org/10.1186/1750-1326-7-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407505/
https://www.ncbi.nlm.nih.gov/pubmed/22537414
http://dx.doi.org/10.1186/1750-1326-7-19

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