Cargando…

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

BACKGROUND: A mutation in the BRI2/ITM2b gene causes familial Danish dementia (FDD). BRI2 is an inhibitor of amyloid-β precursor protein (APP) processing, which is genetically linked to Alzheimer’s disease (AD) pathogenesis. The FDD mutation leads to a loss of BRI2 protein and to increased APP proce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tamayev, Robert, D’Adamio, Luciano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407505/ https://www.ncbi.nlm.nih.gov/pubmed/22537414 http://dx.doi.org/10.1186/1750-1326-7-19

Ejemplares similares

β - but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
por: Tamayev, Robert, et al.
Publicado: (2012)

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
por: Tamayev, Robert, et al.
Publicado: (2012)

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia
por: Biundo, Fabrizio, et al.
Publicado: (2016)

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection
por: Tamayev, Robert, et al.
Publicado: (2012)

An Intracellular Threonine of Amyloid-β Precursor Protein Mediates Synaptic Plasticity Deficits and Memory Loss
por: Lombino, Franco, et al.
Publicado: (2013)

Proteomic Characterization of a Mouse Model of Familial Danish Dementia
por: Vitale, Monica, et al.
Publicado: (2012)

The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains
por: Tamayev, Robert, et al.
Publicado: (2009)

Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43
por: Tambini, Marc D., et al.
Publicado: (2020)

A familial Danish dementia rat shows impaired presynaptic and postsynaptic glutamatergic transmission
por: Yin, Tao, et al.
Publicado: (2021)

Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair glutamatergic synaptic transmission
por: Yin, Tao, et al.
Publicado: (2020)

Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research
por: D'Adamio, Luciano
Publicado: (2023)

BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer’s disease and related dementias
por: Yin, Tao, et al.
Publicado: (2023)

Tyr(682) in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo
por: Barbagallo, Alessia P. M., et al.
Publicado: (2010)

Traumatic vertebral artery dissection presenting with incomplete congruous homonymous quadrantanopia
por: Matti, Albert I, et al.
Publicado: (2010)

The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms
por: Yao, Wen, et al.
Publicado: (2019)

A Congruous Superior Quadrantanopsia Following a Junctional Scotoma Induced by Asperogillosis
por: Park, In Ki, et al.
Publicado: (2011)

Binasal congruous hemianopia secondary to functional visual loss: A case report
por: Tsokolas, Georgios, et al.
Publicado: (2020)

Effects of γ-secretase inhibitors in mouse colon
Publicado: (2012)

A role for tau in learning, memory and synaptic plasticity
por: Biundo, Fabrizio, et al.
Publicado: (2018)

Development of a High-Throughput Assay for Screening of γ-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila γ-Secretase
por: Wang, Lie-Feng, et al.
Publicado: (2009)

The cytotoxicity of γ-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ-secretase inhibition
por: Han, Jianxun, et al.
Publicado: (2009)

Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer’s Risk Variant
por: Tambini, Marc D., et al.
Publicado: (2020)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

CD74 interacts with APP and suppresses the production of Aβ
por: Matsuda, Shuji, et al.
Publicado: (2009)

Initial assessment of the spatial learning, reversal, and sequencing task capabilities of knock-in rats with humanizing mutations in the Aβ-coding region of App
por: Pham, Hoa, et al.
Publicado: (2022)

Beyond amyloid: altered gene function in neurodegenerative diseases
por: Yesiltepe, Metin, et al.
Publicado: (2023)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

Abolishing Tau cleavage by caspases at Aspartate(421) causes memory/synaptic plasticity deficits and pre-pathological Tau alterations
por: Biundo, F, et al.
Publicado: (2017)

Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: Sensitivity, Specificity and Potential for Clinical Use
por: d’Abramo, Cristina, et al.
Publicado: (2020)

Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock‐in rats with increased β‐cleavage of APP
por: Tambini, Marc D., et al.
Publicado: (2019)

Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice
por: Montenegro, Paola, et al.
Publicado: (2023)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

Correction: Abolishing Tau cleavage by caspases at Aspartate(421) causes memory/synaptic plasticity deficits and pre-pathological Tau alterations
por: Biundo, F., et al.
Publicado: (2018)

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1
por: Sogorb-Esteve, Aitana, et al.
Publicado: (2017)

Structure-function relationship of γ-secretase
por: Tomita, Taisuke
Publicado: (2012)

The dynamic conformational landscape of γ-secretase
por: Elad, Nadav, et al.
Publicado: (2015)

Presenilins and γ-Secretase in Membrane Proteostasis
por: Oikawa, Naoto, et al.
Publicado: (2019)

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
por: Jung, Joo In, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_1mqtg8r5lo41ubuoan2bm3eum8