Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice()

Bone is a complex material with a hierarchical multi-scale organization from the molecule to the organ scale. The genetic bone disease, osteogenesis imperfecta, is primarily caused by mutations in the collagen type I genes, resulting in bone fragility. Because the basis of the disease is molecular w...

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Detalles Bibliográficos
Autores principales: Vanleene, Maximilien, Porter, Alexandra, Guillot, Pascale-Valerie, Boyde, Alan, Oyen, Michelle, Shefelbine, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2012
Materias:
Original Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407875/
https://www.ncbi.nlm.nih.gov/pubmed/22449447
http://dx.doi.org/10.1016/j.bone.2012.03.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407875/
https://www.ncbi.nlm.nih.gov/pubmed/22449447
http://dx.doi.org/10.1016/j.bone.2012.03.007

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