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Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice()
Bone is a complex material with a hierarchical multi-scale organization from the molecule to the organ scale. The genetic bone disease, osteogenesis imperfecta, is primarily caused by mutations in the collagen type I genes, resulting in bone fragility. Because the basis of the disease is molecular w...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407875/ https://www.ncbi.nlm.nih.gov/pubmed/22449447 http://dx.doi.org/10.1016/j.bone.2012.03.007 |