Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

Overcoming the resistance of tumours to chemotherapy, often due to downregulation of Bax and Bak, represents a significant clinical challenge. It is therefore important to identify novel apoptosis inducers that bypass Bax and Bak. Potassium channels are emerging as oncological targets and a crucial...

Descripción completa

Detalles Bibliográficos
Autores principales: Leanza, Luigi, Henry, Brian, Sassi, Nicola, Zoratti, Mario, Chandy, K George, Gulbins, Erich, Szabò, Ildikò
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407946/
https://www.ncbi.nlm.nih.gov/pubmed/22496117
http://dx.doi.org/10.1002/emmm.201200235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407946/
https://www.ncbi.nlm.nih.gov/pubmed/22496117
http://dx.doi.org/10.1002/emmm.201200235

Ejemplares similares