Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

The kinase complex mechanistic target of rapamycin 1 (mTORC1) plays an important role in controlling growth and metabolism. We report here that the stepwise formation of phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)) regulates the cell type–specific...

Descripción completa

Detalles Bibliográficos
Autores principales: Bridges, Dave, Ma, Jing-Tyan, Park, Sujin, Inoki, Ken, Weisman, Lois S., Saltiel, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408421/
https://www.ncbi.nlm.nih.gov/pubmed/22696681
http://dx.doi.org/10.1091/mbc.E11-12-1034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408421/
https://www.ncbi.nlm.nih.gov/pubmed/22696681
http://dx.doi.org/10.1091/mbc.E11-12-1034

Ejemplares similares